Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL230854

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc(-n2cc3c(n2)c(N(C(=O)c2ccccc2)C(=O)c2ccccc2)nc2ccccc23)cc1

Basic Information

ChEMBL ID CHEMBL230854
Phase Preclinical
Structure Type MOL
InChI Key JCUWQJFWEUGAOQ-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

498.5
MW (Da)
6.07
ALogP
6
HBA
0
HBD
77.3
PSA (Ų)
0.27
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C31H22N4O3
MW 498.54
Aromatic Rings 6
Heavy Atoms 38
NP-Likeness -0.88

Activity Summary

EC50 1 meas. best 7.95
Ki 1 meas. best 7.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A3
CHEMBL256
EC50 7.95 7.95 11.2 1
Adenosine receptor A3
CHEMBL256
Ki 7.76 7.76 17.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17665891 10.1021/jm070123v Adenosine receptor A3 4
17665891 10.1021/jm070123v Adenosine receptor A1 2
17665891 10.1021/jm070123v Adenosine receptor A2a 2

Data from ChEMBL 36 via Core Engine