Compound Detail
CHEMBL2315641
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2315641 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OKVLOTNUUQZAJD-DHRITJCHSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
387.4
MW (Da)
3.35
ALogP
4
HBA
2
HBD
64.9
PSA (Ų)
0.43
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.0
Ki 1 meas. best 6.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium- and chloride-dependent GABA transporter 1 CHEMBL5445 | Ki | 6.88 | 6.88 | 130.9 | 1 |
| Sodium- and chloride-dependent GABA transporter 1 CHEMBL5445 | IC50 | 6.0 | 6.0 | 997.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium- and chloride-dependent GABA transporter 1 | Ki | = | 130.92 | nM | 6.88 | Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-... | 23336362 |
| Sodium- and chloride-dependent GABA transporter 1 | IC50 | = | 997.7 | nM | 6.0 | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 m... | 23336362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23336362 | 10.1021/jm301800j | Sodium- and chloride-dependent GABA transporter 1 | 3 |
Data from ChEMBL 36 via Core Engine