Compound Detail
CHEMBL2321985
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Basic Information
| ChEMBL ID | CHEMBL2321985 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KUQKKIBQVSFDHX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
170.2
MW (Da)
1.81
ALogP
3
HBA
1
HBD
56.9
PSA (Ų)
0.66
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 3.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Son of sevenless homolog 2 CHEMBL4524041 | Kd | 3.14 | 3.14 | 730000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Son of sevenless homolog 2 | Kd | = | 730000.0 | nM | 3.14 | Binding affinity to biotinylated SOS2 (unknown origin) by surface plasmon resona... | 38156904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 34865870 | 10.1016/j.ejmech.2021.113975 | Unchecked | 3 |
| 24900641 | 10.1021/ml300238z | K562 | 1 |
| 24900641 | 10.1021/ml300238z | T47D | 1 |
| - | 10.6019/CHEMBL3301361 | No relevant target | 1 |
| 38156904 | 10.1021/acs.jmedchem.3c02140 | No relevant target | 1 |
| 38156904 | 10.1021/acs.jmedchem.3c02140 | Son of sevenless homolog 1 | 1 |
| 38156904 | 10.1021/acs.jmedchem.3c02140 | Son of sevenless homolog 2 | 1 |
Data from ChEMBL 36 via Core Engine