Compound Detail
CHEMBL232211
MINOZAC FREE BASE Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL232211 |
| Name | MINOZAC FREE BASE |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | ASVQCPUSQNFHHU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
4
Known Names
2
Indications
Molecular Properties
332.4
MW (Da)
2.57
ALogP
6
HBA
0
HBD
58.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Cognitive Dysfunction Drug-Related Side Effects and Adverse Reactions
Activity Summary
IC50 1 meas. best 5.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.08 | 5.08 | 8300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 8300.0 | nM | 5.08 | Inhibition of IL1 beta production in glia cells | 17079143 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17079143 | 10.1016/j.bmcl.2006.10.028 | Mus musculus | 8 |
| 35931005 | 10.1016/j.ejmech.2022.114597 | BV-2 | 8 |
| 17079143 | 10.1016/j.bmcl.2006.10.028 | Unchecked | 1 |
| 17079143 | 10.1016/j.bmcl.2006.10.028 | No relevant target | 1 |
| 17079143 | 10.1016/j.bmcl.2006.10.028 | ADMET | 1 |
| 17079143 | 10.1016/j.bmcl.2006.10.028 | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine