Compound Detail
CHEMBL2323100
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Basic Information
| ChEMBL ID | CHEMBL2323100 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LDRZWGWBOYORGD-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
1
PK Parameters
7
Publications
0
Known Names
Molecular Properties
472.9
MW (Da)
4.06
ALogP
9
HBA
1
HBD
122.8
PSA (Ų)
0.45
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 6.62 | 6.615 | 240.0 | 2 |
| Sodium channel protein type 5 subunit alpha CHEMBL1980 | IC50 | 4.59 | 4.59 | 25448.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 68.0 | mL.min-1.g-1 | Homo sapiens |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 239.99 | nM | 6.62 | Inhibition of NaV1.7 ion channel (unknown origin) | 23177785 |
| Sodium channel protein type 9 subunit alpha | IC50 | = | 244.0 | nM | 6.61 | Inhibition of human NaV1.7 expressed in HEK cells assessed as half inactivation ... | 28682065 |
| Sodium channel protein type 5 subunit alpha | IC50 | = | 25448.0 | nM | 4.59 | Inhibition of human NaV1.5 expressed in HEK cells assessed as half inactivation ... | 28682065 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23177785 | 10.1016/j.bmcl.2012.10.102 | Sodium channel protein type 9 subunit alpha | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | Sodium channel protein type 5 subunit alpha | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | Sodium channel protein type 9 subunit alpha | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | Cytochrome P450 3A4 | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | Cytochrome P450 2C9 | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | Liver | 1 |
| 28682065 | 10.1021/acs.jmedchem.7b00598 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine