Compound Detail
CHEMBL2323118
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Basic Information
| ChEMBL ID | CHEMBL2323118 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MBYHRKYXXULHCG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
439.5
MW (Da)
2.02
ALogP
10
HBA
0
HBD
90.7
PSA (Ų)
0.59
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform CHEMBL3130 | IC50 | 5.95 | 5.95 | 1120.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | IC50 | = | 1120.0 | nM | 5.95 | Inhibition of PI3Kdelta (unknown origin) expressed in SF21 cells using phosphati... | 23265896 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23265896 | 10.1016/j.bmcl.2012.11.076 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
| 23265896 | 10.1016/j.bmcl.2012.11.076 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 1 |
| 23265896 | 10.1016/j.bmcl.2012.11.076 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 23265896 | 10.1016/j.bmcl.2012.11.076 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | 1 |
Data from ChEMBL 36 via Core Engine