Compound Detail
CHEMBL2323144
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Basic Information
| ChEMBL ID | CHEMBL2323144 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BOSKSAXLPWCOTQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
246.3
MW (Da)
1.74
ALogP
4
HBA
0
HBD
51.1
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.97
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 4.97 | 4.97 | 10820.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 10820.0 | nM | 4.97 | Inhibition of telomerase-mediated supercoiling activity in human MGC803 cells af... | 23265905 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23265905 | 10.1016/j.bmcl.2012.11.101 | Molecular identity unknown | 1 |
| 23265905 | 10.1016/j.bmcl.2012.11.101 | Telomerase reverse transcriptase | 1 |
| 29438888 | 10.1016/j.ejmech.2018.02.002 | Acetylcholinesterase | 1 |
| 29438888 | 10.1016/j.ejmech.2018.02.002 | Cholinesterase | 1 |
Data from ChEMBL 36 via Core Engine