Compound Detail
CHEMBL2323534
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O=C(N[C@@H]1C[C@@H](O)c2ccccc21)c1cc(Cc2n[nH]c(=O)c3ccccc23)ccc1F
Basic Information
| ChEMBL ID | CHEMBL2323534 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XVLGMXJEFBHNKQ-FYYLOGMGSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
429.4
MW (Da)
3.56
ALogP
4
HBA
3
HBD
95.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 CHEMBL3105 | IC50 | 6.24 | 6.24 | 570.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 | IC50 | = | 570.0 | nM | 6.24 | Inhibition of human recombinant PARP1 after 1 hr by ELISA | 23473053 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23473053 | 10.1021/jm301825t | ADMET | 2 |
| 23473053 | 10.1021/jm301825t | V79 | 1 |
| 23473053 | 10.1021/jm301825t | Poly [ADP-ribose] polymerase 1 | 1 |
Data from ChEMBL 36 via Core Engine