Compound Detail
CHEMBL2325483
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Basic Information
| ChEMBL ID | CHEMBL2325483 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASDFSRNMHPUURW-MRXNPFEDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
428.5
MW (Da)
2.51
ALogP
4
HBA
2
HBD
64.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phospholipase D1 CHEMBL2536 | IC50 | 6.12 | 6.12 | 760.0 | 1 |
| Phospholipase D2 CHEMBL2734 | IC50 | 5.97 | 5.97 | 1060.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phospholipase D1 | IC50 | = | 760.0 | nM | 6.12 | Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorp... | 23445448 |
| Phospholipase D2 | IC50 | = | 1060.0 | nM | 5.97 | Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-but... | 23445448 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23445448 | 10.1021/jm301782e | Phospholipase D2 | 1 |
| 23445448 | 10.1021/jm301782e | Phospholipase D1 | 1 |
Data from ChEMBL 36 via Core Engine