Compound Detail
CHEMBL2333600
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Basic Information
| ChEMBL ID | CHEMBL2333600 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GUFPBYBPFUDKIX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
421.8
MW (Da)
2.99
ALogP
7
HBA
1
HBD
86.3
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ephrin type-B receptor 4 CHEMBL5147 | IC50 | 6.52 | 6.09 | 300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ephrin type-B receptor 4 | IC50 | = | 300.0 | nM | 6.52 | Inhibition of EphB4 (unknown origin) transfected in CHO cells using Z'-LYTE TYR-... | 23253074 |
| Ephrin type-B receptor 4 | IC50 | = | 2200.0 | nM | 5.66 | Inhibition of human myc-tagged full length EphB4 expressed in MEF cells assessed... | 23253074 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23253074 | 10.1021/jm301187e | Ephrin type-B receptor 4 | 3 |
Data from ChEMBL 36 via Core Engine