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Compound Detail

CHEMBL2337374

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Nc1nc(Nc2ccccc2)c2c(n1)[nH]c1cccc(Cl)c12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2337374
Phase Preclinical
Structure Type MOL
InChI Key FSZOXOIZWIXVKA-UHFFFAOYSA-N
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

309.8
MW (Da)
4.09
ALogP
4
HBA
3
HBD
79.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H12ClN5
MW 309.76
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -1.14

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
23434139 10.1016/j.bmc.2013.01.040 A-431 1
23434139 10.1016/j.bmc.2013.01.040 Platelet-derived growth factor receptor beta 1
23434139 10.1016/j.bmc.2013.01.040 Epidermal growth factor receptor 1
23434139 10.1016/j.bmc.2013.01.040 Vascular endothelial growth factor receptor 2 1

Data from ChEMBL 36 via Core Engine