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Compound Detail

CHEMBL23388

TETRAHYDROHOMOFOLATE
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Nc1nc(O)c2c(n1)NC[C@H](CCNc1ccc(C(=O)NC(CCC(=O)O)C(=O)O)cc1)N2
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL23388
Name TETRAHYDROHOMOFOLATE
Phase Preclinical
Structure Type MOL
InChI Key SVEJTXIHPDUQLZ-UEWDXFNNSA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

459.5
MW (Da)
0.52
ALogP
10
HBA
8
HBD
211.8
PSA (Ų)
0.24
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H25N7O6
MW 459.46
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness -0.01

Activity Summary

IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
2498518 10.1021/jm00126a022 Trifunctional purine biosynthetic protein adenosine-3 2

Data from ChEMBL 36 via Core Engine