Compound Detail
CHEMBL2348993
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2348993 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CKFGBDPRYSAZQN-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
445.5
MW (Da)
3.47
ALogP
8
HBA
2
HBD
115.4
PSA (Ų)
0.47
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 8.33 | 8.33 | 4.7 | 1 |
| HUVEC CHEMBL613979 | IC50 | 7.01 | 7.01 | 97.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 4.7 | nM | 8.33 | Inhibition of VEGFR2 (unknown origin) using biotinylated poly(Glu:Tyr) as substr... | 23498918 |
| HUVEC | IC50 | = | 97.0 | nM | 7.01 | Antiproliferative activity against VEGF-stimulated HUVECs after 5 days by WST-8 ... | 23498918 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23498918 | 10.1016/j.bmc.2013.01.074 | HUVEC | 1 |
| 23498918 | 10.1016/j.bmc.2013.01.074 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine