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Compound Detail

CHEMBL2368118

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C[C@H]1[C@@H](CCc2ccc(C(=O)O)cc2)O[C@@H]2O[C@]3(C)CC[C@H]4[C@H](C)CC[C@@H]1[C@@]24OO3

Basic Information

ChEMBL ID CHEMBL2368118
Phase Preclinical
Structure Type MOL
InChI Key ULFXMPVBUZAXFP-PTBRYTJWSA-N
0
Targets
0
Activities
0
Assay Types
3
PK Parameters
8
Publications
0
Known Names

Molecular Properties

416.5
MW (Da)
4.57
ALogP
5
HBA
1
HBD
74.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H32O6
MW 416.51
Aromatic Rings 1
Heavy Atoms 30
NP-Likeness 2.38

Pharmacokinetic Data

Parameter Value Units Species
T1/2 258.66 hr -
T1/2 13.1 hr -
T1/2 258.66 hr -

Literature References

PubMed DOI Target Context # Activities
12383020 10.1021/jm020244p Mus musculus 7
12383020 10.1021/jm020244p Plasmodium falciparum 2
33508479 10.1016/j.ejmech.2021.113193 Plasmodium falciparum 2
12383020 10.1021/jm020244p ADMET 1
16380253 10.1016/j.bmcl.2005.11.074 Gallus gallus 1
- 10.1039/C2MD00277A ADMET 1
33508479 10.1016/j.ejmech.2021.113193 Unchecked 1
33508479 10.1016/j.ejmech.2021.113193 Plasmodium chabaudi 1

Data from ChEMBL 36 via Core Engine