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Compound Detail

CHEMBL2370245

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CC[C@H](C)[C@@H]1NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](NC(=O)[C@H](NC(C)=O)C(c2ccccc2)c2ccccc2)CSSC[C@@H](C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)NC1=O

Basic Information

ChEMBL ID CHEMBL2370245
Phase Preclinical
Structure Type BOTH
InChI Key DLTKIIYVGQMDMK-HKVTWNDMSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

902.1
MW (Da)
2.47
ALogP
10
HBA
9
HBD
265.0
PSA (Ų)
0.08
QED
2
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H51N7O10S2
MW 902.07
Aromatic Rings 4
Heavy Atoms 63
NP-Likeness 0.53

Literature References

PubMed DOI Target Context # Activities
7636842 10.1021/jm00015a003 Endothelin-1 receptor 1
7636842 10.1021/jm00015a003 Endothelin receptor type B 1

Data from ChEMBL 36 via Core Engine