Compound Detail
CHEMBL2372859
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CCCC[C@H](NC(C)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O
Basic Information
| ChEMBL ID | CHEMBL2372859 |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | VYTCDVWNUIRJEU-MFVUMRCOSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
1042.2
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 9.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL3719 | EC50 | 9.68 | 9.68 | 0.2 | 1 |
| Melanocyte-stimulating hormone receptor CHEMBL4077 | EC50 | 9.34 | 9.34 | 0.5 | 1 |
| Melanocortin receptor 3 CHEMBL4774 | EC50 | 8.96 | 8.96 | 1.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | EC50 | = | 0.21 | nM | 9.68 | Activity at mouse MC4R expressed in HEK293 cells assessed as cAMP accumulation b... | 25347033 |
| Melanocyte-stimulating hormone receptor | EC50 | = | 0.46 | nM | 9.34 | Activity at mouse MC1R expressed in HEK293 cells assessed as cAMP accumulation b... | 25347033 |
| Melanocortin receptor 3 | EC50 | = | 1.1 | nM | 8.96 | Activity at mouse MC3R expressed in HEK293 cells assessed as cAMP accumulation b... | 25347033 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2535874 | 10.1021/jm00121a032 | Melanocyte-stimulating hormone receptor | 2 |
| 2535874 | 10.1021/jm00121a032 | Unchecked | 2 |
| 25347033 | 10.1021/jm501027w | Melanocortin receptor 5 | 1 |
| 25347033 | 10.1021/jm501027w | Melanocortin receptor 4 | 1 |
| 25347033 | 10.1021/jm501027w | Melanocortin receptor 3 | 1 |
| 25347033 | 10.1021/jm501027w | Melanocyte-stimulating hormone receptor | 1 |
Data from ChEMBL 36 via Core Engine