Compound Detail
CHEMBL2373300
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL2373300 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FFMDBPCCMUXCED-UUEMRFSQSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
187.2
MW (Da)
-0.10
ALogP
3
HBA
3
HBD
100.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 6 meas. best 5.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Excitatory amino acid transporter 2 CHEMBL4973 | Ki | 5.18 | 5.18 | 6600.0 | 1 |
| Excitatory amino acid transporter 3 CHEMBL2721 | Ki | 4.3 | 4.29 | 50118.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Excitatory amino acid transporter 2 | Ki | = | 6600.0 | nM | 5.18 | Inhibition of human GLT1 expressed in Xenopus laevis Oocytes assessed as reducti... | 20812729 |
| Excitatory amino acid transporter 3 | Ki | = | 50118.72 | nM | 4.3 | Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential ... | 17064071 |
| Excitatory amino acid transporter 3 | Ki | = | 52000.0 | nM | 4.28 | Inhibition of human EAAT3 expressed in HEK293 cells by FLIPR membrane potential ... | 17064071 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17064071 | 10.1021/jm060822s | Excitatory amino acid transporter 2 | 2 |
| 17064071 | 10.1021/jm060822s | Excitatory amino acid transporter 3 | 2 |
| 17064071 | 10.1021/jm060822s | Excitatory amino acid transporter 1 | 1 |
| 20812729 | 10.1021/jm100959g | Excitatory amino acid transporter 2 | 1 |
Data from ChEMBL 36 via Core Engine