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Compound Detail

CHEMBL2373361

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C/C(=C\c1ncccc1C)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1

Basic Information

ChEMBL ID CHEMBL2373361
Phase Preclinical
Structure Type MOL
InChI Key CUMNCKXCXKVCQP-DPVOWAMBSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

501.7
MW (Da)
4.42
ALogP
7
HBA
2
HBD
109.2
PSA (Ų)
0.46
QED
1
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H43NO6
MW 501.66
Aromatic Rings 1
Heavy Atoms 36
NP-Likeness 2.11

Literature References

PubMed DOI Target Context # Activities
16134928 10.1021/jm050524f 1A9 2
16134928 10.1021/jm050524f 1A9/ptx-10 2
16134928 10.1021/jm050524f 1A9/ptx-22 2
16134928 10.1021/jm050524f Tubulin beta-4B chain 1

Data from ChEMBL 36 via Core Engine