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Compound Detail

CHEMBL237535

PYGENIC ACID A
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C[C@H]1[C@H](C)CC[C@]2(C(=O)O)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@H]12

Basic Information

ChEMBL ID CHEMBL237535
Name PYGENIC ACID A
Phase Preclinical
Structure Type MOL
InChI Key HFGSQOYIOKBQOW-RFMFWNHYSA-N
0
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

472.7
MW (Da)
6.06
ALogP
3
HBA
3
HBD
77.8
PSA (Ų)
0.41
QED
1
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C30H48O4
MW 472.71
Aromatic Rings 0
Heavy Atoms 34
NP-Likeness 3.26

Activity Summary

IC50 2 meas.

Literature References

PubMed DOI Target Context # Activities
26259803 10.1016/j.bmcl.2015.07.029 Mus musculus 4
17869102 10.1016/j.bmcl.2007.08.057 Unchecked 1
18517260 10.1021/jm8000949 Glycogen phosphorylase, muscle form 1
25245917 10.1021/np500509q RAW264.7 1
32033878 10.1016/j.bmc.2019.115229 Pseudomonas aeruginosa 1

Data from ChEMBL 36 via Core Engine