Compound Detail
CHEMBL2377752
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CS(=O)(=O)c1ccc2nc(NC(=O)N(CCC(c3ccccc3)c3ccccc3)CCN3CCOCC3)sc2c1
Basic Information
| ChEMBL ID | CHEMBL2377752 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FBYLWVFZBOAEKD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
578.8
MW (Da)
5.09
ALogP
7
HBA
1
HBD
91.8
PSA (Ų)
0.28
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor CHEMBL1878 | EC50 | 7.1 | 7.1 | 80.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Extracellular calcium-sensing receptor | EC50 | = | 80.0 | nM | 7.1 | Positive allosteric modulation of human CaSR expressed in CHO cells assessed as ... | 23499504 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23499504 | 10.1016/j.bmcl.2013.01.077 | Extracellular calcium-sensing receptor | 1 |
Data from ChEMBL 36 via Core Engine