Compound Detail
CHEMBL2385422
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Basic Information
| ChEMBL ID | CHEMBL2385422 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BYNYDTWPAMVZGY-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
477.5
MW (Da)
3.82
ALogP
5
HBA
2
HBD
97.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.04
Ki 1 meas. best 9.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | Ki | 9.05 | 9.05 | 0.9 | 1 |
| Transient receptor potential cation channel subfamily V member 1 CHEMBL4794 | IC50 | 7.04 | 7.04 | 90.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Ki | = | 0.9 | nM | 9.05 | Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibiti... | 23685943 |
| Transient receptor potential cation channel subfamily V member 1 | IC50 | = | 90.1 | nM | 7.04 | Antagonist activity at human TRPV1 expressed in CHOK1 cells assessed as inhibiti... | 23685943 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23685943 | 10.1016/j.ejmech.2013.04.003 | Transient receptor potential cation channel subfamily V member 1 | 2 |
Data from ChEMBL 36 via Core Engine