Compound Detail
CHEMBL2386757
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Basic Information
| ChEMBL ID | CHEMBL2386757 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BCZQEXKZJLTOFI-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
418.2
MW (Da)
3.98
ALogP
6
HBA
2
HBD
93.8
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | IC50 | 6.71 | 6.71 | 194.4 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 194.4 | nM | 6.71 | Inhibition of recombinant DYRK1A (unknown origin) after 120 mins in presence of ... | 24900699 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | IC50 | = | 194.4 | nM | 6.71 | HotSpot Technology Assay: The DYRK1A and DYRK1B kinase assays to determine IC50 ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900699 | 10.1021/ml400137s | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
Data from ChEMBL 36 via Core Engine