Compound Detail
CHEMBL238884
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Basic Information
| ChEMBL ID | CHEMBL238884 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IYAGTYUXIZQQHR-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
443.7
MW (Da)
3.66
ALogP
4
HBA
3
HBD
102.2
PSA (Ų)
0.16
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.87
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | EC50 | 5.87 | 5.87 | 1349.0 | 1 |
| ATP-sensitive inward rectifier potassium channel 11 CHEMBL1886 | EC50 | 5.82 | 5.82 | 1513.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | EC50 | = | 1348.96 | nM | 5.87 | Activity at Kir6.2 channel in Landrace pig bladder detrusor assessed as relaxati... | 17973362 |
| ATP-sensitive inward rectifier potassium channel 11 | EC50 | = | 1513.56 | nM | 5.82 | Channel opening activity at human bladder Kir6.2 channel containing SUR2B expres... | 17973362 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17973362 | 10.1021/jm7010194 | ATP-sensitive inward rectifier potassium channel 11 | 1 |
| 17973362 | 10.1021/jm7010194 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine