Compound Detail

CHEMBL2391146

ANGIOTENSIN

🧪 Phase III

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🧪 Phase III

CC(C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)O)C(C)C

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL2391146
Name	ANGIOTENSIN
Phase	Phase III
Structure Type	BOTH
InChI Key	JSQIKKVBLLHQSQ-AWJAZODESA-N

Known Names

Angiotensin

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Indications

Molecular Properties

956.1

MW (Da)

-2.72

ALogP

HBA

HBD

406.3

PSA (Å²)

0.03

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Protein
Chirality	Single Enantiomer

Extended Properties

Molecular Formula	C43H65N13O12
MW	956.07
Aromatic Rings	2
Heavy Atoms	68
NP-Likeness	0.03

Indications

Hypertension Kidney Diseases Kidney Failure, Chronic

Activity Summary

IC50 2 meas. best 9.89

Ki 1 meas. best 9.05

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Type-2 angiotensin II receptor CHEMBL4607	IC50	9.89	9.315	0.1	2
Type-2 angiotensin II receptor CHEMBL4607	Ki	9.05	9.05	0.9	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Type-2 angiotensin II receptor	IC50	=	0.13	nM	9.89	Binding affinity to human angiotensin AT2 receptor by radioligand displacement a...	23582449
Type-2 angiotensin II receptor	Ki	=	0.898	nM	9.05	Receptor Binding Assay : 120 μL membrane (5 mg protein/well) was incubated w...	-
Type-2 angiotensin II receptor	IC50	=	1.8	nM	8.74	Receptor Binding Assay : 120 μL membrane (5 mg protein/well) was incubated w...	-

Literature References

PubMed	DOI	Target Context	# Activities
23582449	10.1016/j.bmc.2013.03.016	Type-2 angiotensin II receptor	1

Data from ChEMBL 36 via Core Engine