Compound Detail
CHEMBL2392932
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Basic Information
| ChEMBL ID | CHEMBL2392932 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BIYGKGWPQHRVJY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
463.4
MW (Da)
6.98
ALogP
4
HBA
1
HBD
50.7
PSA (Ų)
0.31
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 1 CHEMBL2474 | EC50 | 7.2 | 7.2 | 63.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 1 | EC50 | = | 63.0 | nM | 7.2 | Inhibition of human recombinant full-length cytosolic METAP1 expressed in Escher... | 23507151 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23507151 | 10.1016/j.bmc.2013.02.023 | Unchecked | 1 |
| 23507151 | 10.1016/j.bmc.2013.02.023 | Methionine aminopeptidase 2 | 1 |
| 23507151 | 10.1016/j.bmc.2013.02.023 | Methionine aminopeptidase 1 | 1 |
Data from ChEMBL 36 via Core Engine