Compound Detail
CHEMBL2398100
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Basic Information
| ChEMBL ID | CHEMBL2398100 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HECJMTPEVWQFCY-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
230.1
MW (Da)
2.76
ALogP
3
HBA
1
HBD
33.1
PSA (Ų)
0.75
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 CHEMBL4637 | EC50 | 4.14 | 4.14 | 72900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5'-AMP-activated protein kinase catalytic subunit alpha-2 | EC50 | = | 72900.0 | nM | 4.14 | Activation of AMPK in rat L6 cells assessed as increase of [3H]dGlc uptake after... | 23750537 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23750537 | 10.1021/jm4001488 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | 5 |
| 23750537 | 10.1021/jm4001488 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine