Compound Detail
CHEMBL2403487
PHLOROGLUCINALDEHYDE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL2403487 |
| Name | PHLOROGLUCINALDEHYDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BTQAJGSMXCDDAJ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
10
Publications
0
Known Names
Molecular Properties
154.1
MW (Da)
0.62
ALogP
4
HBA
3
HBD
77.8
PSA (Ų)
0.52
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.34 | 5.34 | 4600.0 | 1 |
| Radical scavenging activity CHEMBL613712 | IC50 | 4.15 | 4.15 | 71400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 4600.0 | nM | 5.34 | Inhibition of alpha-glucosidase (unknown origin) using PNPG as substrate assesse... | - |
| Radical scavenging activity | IC50 | = | 71400.0 | nM | 4.15 | Antioxidant activity assessed as DPPH radical scavenging activity after 30 min | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1007/s00044-010-9461-8 | Rattus norvegicus | 4 |
| 26719209 | 10.1016/j.bmc.2015.12.021 | Amyloid-beta precursor protein | 3 |
| - | 10.1007/s00044-010-9461-8 | Unchecked | 2 |
| 23769638 | 10.1016/j.bmcl.2013.05.030 | Oxysterols receptor LXR-beta | 2 |
| 23769638 | 10.1016/j.bmcl.2013.05.030 | Oxysterols receptor LXR-alpha | 2 |
| 24803365 | 10.1016/j.bmcl.2014.04.026 | NON-PROTEIN TARGET | 2 |
| 37839345 | 10.1016/j.ejmech.2023.115823 | Staphylococcus aureus | 2 |
| - | 10.1007/s00044-010-9461-8 | Radical scavenging activity | 1 |
| 24803365 | 10.1016/j.bmcl.2014.04.026 | Radical scavenging activity | 1 |
| 26719209 | 10.1016/j.bmc.2015.12.021 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine