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Compound Detail

CHEMBL241479

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CCc1ccc(O[C@H](C)CCOc2ccc(CCC(=O)O)c(CC)c2)c(-c2ccccn2)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL241479
Phase Preclinical
Structure Type MOL
InChI Key GYZNATQOXOBZSD-HXUWFJFHSA-N
3
Targets
9
Activities
2
Assay Types
4
PK Parameters
8
Publications
0
Known Names

Molecular Properties

447.6
MW (Da)
6.13
ALogP
4
HBA
1
HBD
68.7
PSA (Ų)
0.36
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H33NO4
MW 447.58
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.44

Activity Summary

IC50 6 meas. best 8.52
EC50 3 meas. best 8.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Peroxisome proliferator-activated receptor delta
CHEMBL3979
 IC50 8.52 8.52 3.0 2
Peroxisome proliferator-activated receptor delta
CHEMBL3979
 EC50 8.15 8.15 7.0 1
Peroxisome proliferator-activated receptor gamma
CHEMBL235
 IC50 7.46 7.46 35.0 2
Peroxisome proliferator-activated receptor gamma
CHEMBL235
 EC50 6.78 6.78 167.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
 EC50 5.54 5.54 2850.0 1
Peroxisome proliferator-activated receptor alpha
CHEMBL239
 IC50 5.13 5.13 7345.1 2

Pharmacokinetic Data

Parameter Value Units Species
AUC 75500.0 ng.hr.mL-1 Rattus norvegicus
CL 1.9 mL.min-1.kg-1 Rattus norvegicus
F 71.0 % Rattus norvegicus
T1/2 3.0 hr Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Peroxisome proliferator-activated receptor delta IC50 = 3.0 nM 8.52 Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phe... 17129725
Peroxisome proliferator-activated receptor delta IC50 = 2.999 nM 8.52 Agonist activity at PPARdelta 22564380
Peroxisome proliferator-activated receptor delta EC50 = 7.0 nM 8.15 Agonist activity at human Gal4-PPARdelta expressed in CV1 cells by transactivati... 17129725
Peroxisome proliferator-activated receptor gamma IC50 = 35.0 nM 7.46 Displacement of [3H]2-methyl-2-(4-{3-[porpyl-(5-pyridin-2yl-thiophene-2-sulfonyl... 17129725
Peroxisome proliferator-activated receptor gamma IC50 = 34.99 nM 7.46 Agonist activity at PPARgamma 22564380
Peroxisome proliferator-activated receptor gamma EC50 = 167.0 nM 6.78 Agonist activity at PPARgamma in CV1 cells by transactivation assay 17129725
Peroxisome proliferator-activated receptor alpha EC50 = 2850.0 nM 5.54 Agonist activity at human Gal4-PPARalpha expressed in CV1 cells by transactivati... 17129725
Peroxisome proliferator-activated receptor alpha IC50 = 7350.0 nM 5.13 Displacement of [3H]2-(4-{2-[3-(2,4-difluoro-phenyl)-1-heptyl-ureido]-ethyl}-phe... 17129725
Peroxisome proliferator-activated receptor alpha IC50 = 7345.14 nM 5.13 Agonist activity at PPARalpha 22564380

Literature References

PubMed DOI Target Context # Activities
17129725 10.1016/j.bmcl.2006.11.029 Rattus norvegicus 12
17129725 10.1016/j.bmcl.2006.11.029 Peroxisome proliferator-activated receptor alpha 2
17129725 10.1016/j.bmcl.2006.11.029 Peroxisome proliferator-activated receptor gamma 2
17129725 10.1016/j.bmcl.2006.11.029 Peroxisome proliferator-activated receptor delta 2
17129725 10.1016/j.bmcl.2006.11.029 Mus musculus 2
22564380 10.1016/j.bmc.2012.04.005 Peroxisome proliferator-activated receptor alpha 1
22564380 10.1016/j.bmc.2012.04.005 Peroxisome proliferator-activated receptor delta 1
22564380 10.1016/j.bmc.2012.04.005 Peroxisome proliferator-activated receptor gamma 1

Data from ChEMBL 36 via Core Engine