Compound Detail
CHEMBL2419973
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Basic Information
| ChEMBL ID | CHEMBL2419973 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XLXFQKDKASNFHJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
295.4
MW (Da)
1.82
ALogP
6
HBA
1
HBD
73.2
PSA (Ų)
0.93
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| CREB-binding protein CHEMBL5747 | IC50 | 5.78 | 5.78 | 1670.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| CREB-binding protein | IC50 | = | 1670.0 | nM | 5.78 | Inhibition of recombinant human CBP using biotinylated histone H3 (1 to 21 amino... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23850103 | 10.1016/j.bmc.2013.06.027 | Cutibacterium acnes | 3 |
| - | 10.1039/C4MD00245H | CREB-binding protein | 2 |
| 23850103 | 10.1016/j.bmc.2013.06.027 | Mycobacterium tuberculosis | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase KAT2B | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase KAT2A | 1 |
| - | 10.1039/C4MD00245H | Histone acetyltransferase p300 | 1 |
| - | 10.1039/C4MD00245H | LNCaP | 1 |
| - | 10.1039/C4MD00245H | HL-60 | 1 |
Data from ChEMBL 36 via Core Engine