Compound Detail
CHEMBL2425366
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c1cc2nc3c4ccc5cc6cc(ccc6nc53)CNCCNCCNCc3ccc5nc6c(ccc7cc8cc(ccc8nc76)CNCCNCCNCc1cc2c4)cc5c3
Basic Information
| ChEMBL ID | CHEMBL2425366 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VAUSMGHXWKWHEM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
815.0
MW (Da)
7.74
ALogP
10
HBA
6
HBD
123.7
PSA (Ų)
0.07
QED
3
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Telomerase reverse transcriptase CHEMBL2916 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Telomerase reverse transcriptase | IC50 | = | 130.0 | nM | 6.89 | Inhibition of telomerase (unknown origin) by TRAP assay | 23974014 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23974014 | 10.1016/j.ejmech.2013.07.022 | Telomerase reverse transcriptase | 1 |
Data from ChEMBL 36 via Core Engine