Compound Detail
CHEMBL243531
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O=C(c1c(F)cc(F)cc1F)N1N=C(c2ccc(Cl)cc2)SC1c1cccc2c1OC(F)(F)O2
Basic Information
| ChEMBL ID | CHEMBL243531 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUOGEZKRWWZZDU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
512.8
MW (Da)
6.33
ALogP
5
HBA
0
HBD
51.1
PSA (Ų)
0.38
QED
2
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta CHEMBL4093 | EC50 | 6.1 | 6.1 | 800.0 | 1 |
| Oxysterols receptor LXR-alpha CHEMBL2808 | EC50 | 5.41 | 5.41 | 3900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oxysterols receptor LXR-beta | EC50 | = | 800.0 | nM | 6.1 | Agonist activity at GAL-linked human LXRbeta expressed in THP1 cells assessed as... | 17665897 |
| Oxysterols receptor LXR-alpha | EC50 | = | 3900.0 | nM | 5.41 | Agonist activity at GAL-linked human LXRalpha expressed in THP1 cells assessed a... | 17665897 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17665897 | 10.1021/jm070453f | Oxysterols receptor LXR-alpha | 2 |
| 17665897 | 10.1021/jm070453f | Oxysterols receptor LXR-beta | 2 |
| 17665897 | 10.1021/jm070453f | THP-1 | 2 |
Data from ChEMBL 36 via Core Engine