Compound Detail
CHEMBL248515
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Basic Information
| ChEMBL ID | CHEMBL248515 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XGIXEBKNKXHCMD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
354.4
MW (Da)
5.30
ALogP
4
HBA
2
HBD
79.9
PSA (Ų)
0.65
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 9.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thyroid hormone receptor CHEMBL2111462 | EC50 | 9.52 | 9.52 | 0.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor | EC50 | = | 0.3 | nM | 9.52 | Agonist activity at THR in HepG2 cells by whole cell assay | 17499989 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17499989 | 10.1016/j.bmcl.2007.04.085 | Mus musculus | 7 |
| 17499989 | 10.1016/j.bmcl.2007.04.085 | Thyroid hormone receptor | 1 |
Data from ChEMBL 36 via Core Engine