Compound Detail
CHEMBL251701
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Basic Information
| ChEMBL ID | CHEMBL251701 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FWBOSTMPMJAEKL-OALUTQOASA-N |
1
Targets
2
Activities
1
Assay Types
9
PK Parameters
5
Publications
0
Known Names
Molecular Properties
415.5
MW (Da)
4.56
ALogP
6
HBA
2
HBD
64.0
PSA (Ų)
0.48
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 7.54 | 7.31 | 29.0 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 20.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 15.0 | mL.min-1.kg-1 | Mus musculus |
| Cmax | 0.5 | umol/Kg | Mus musculus |
| Cmax | 3780.0 | nM | Mus musculus |
| F | 100.0 | % | Mus musculus |
| Fu | 0.065 | - | Mus musculus |
| T1/2 | 8.6 | hr | Mus musculus |
| Tmax | 0.26 | hr | Mus musculus |
| Tmax | 24.0 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 29.0 | nM | 7.54 | Displacement of [125I]MCH from human MCHR1 expressed in HEK293 cells | 17532215 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 83.0 | nM | 7.08 | Antagonist activity at human MCHR1 expressed in HEK293 cells assessed as [35S]GT... | 17532215 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17532215 | 10.1016/j.bmcl.2007.05.034 | Mus musculus | 9 |
| - | 10.6019/CHEMBL3301361 | ADMET | 3 |
| 17532215 | 10.1016/j.bmcl.2007.05.034 | Melanin-concentrating hormone receptor 1 | 2 |
| 17532215 | 10.1016/j.bmcl.2007.05.034 | Liver microsomes | 1 |
| 17532215 | 10.1016/j.bmcl.2007.05.034 | Plasma | 1 |
Data from ChEMBL 36 via Core Engine