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Compound Detail

CHEMBL254281

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O=C(Cc1ccc(F)cc1)NC(=O)Nc1ccc(Oc2ncnn3ccc(Cl)c23)c(F)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL254281
Phase Preclinical
Structure Type MOL
InChI Key KIOMLSKUXPYSLZ-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

457.8
MW (Da)
4.34
ALogP
6
HBA
2
HBD
97.6
PSA (Ų)
0.46
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H14ClF2N5O3
MW 457.82
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -2.11

Literature References

PubMed DOI Target Context # Activities
18289854 10.1016/j.bmcl.2008.01.121 Hepatocyte growth factor receptor 1

Data from ChEMBL 36 via Core Engine