Compound Detail
CHEMBL255023
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Basic Information
| ChEMBL ID | CHEMBL255023 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XQWLRVUWANJCSB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
335.8
MW (Da)
5.25
ALogP
3
HBA
1
HBD
61.3
PSA (Ų)
0.40
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 10 subunit alpha CHEMBL5158 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 10 subunit alpha | IC50 | = | 30.0 | nM | 7.52 | Inhibition of mouse recombinant Nav 1.8 channel expressed in HEK293 cells by iso... | 18176998 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18176998 | 10.1021/jm070637u | Sodium channel protein type 10 subunit alpha | 7 |
| 18176998 | 10.1021/jm070637u | NON-PROTEIN TARGET | 4 |
| 18176998 | 10.1021/jm070637u | Sodium channel protein type 9 subunit alpha | 2 |
| 18176998 | 10.1021/jm070637u | Sodium channel protein type 2 subunit alpha | 2 |
| 18176998 | 10.1021/jm070637u | Sodium channel protein type 3 subunit alpha | 2 |
| 18176998 | 10.1021/jm070637u | Sodium channel protein type 5 subunit alpha | 2 |
| 18176998 | 10.1021/jm070637u | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine