Compound Detail
CHEMBL255902
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Basic Information
| ChEMBL ID | CHEMBL255902 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ACPWZRGLIIWDAZ-SECBINFHSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
2
Publications
0
Known Names
Molecular Properties
357.4
MW (Da)
2.61
ALogP
7
HBA
2
HBD
97.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 3966.59 | ng.hr.mL-1 | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 27.0 | nM | 7.57 | Inhibition of human VEGFR2 | 18395443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18395443 | 10.1016/j.bmcl.2008.03.057 | Vascular endothelial growth factor receptor 2 | 1 |
| 18395443 | 10.1016/j.bmcl.2008.03.057 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine