Compound Detail
CHEMBL257978
DABUZALGRON 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL257978 |
| Name | DABUZALGRON |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | FOYWMEJSRSBQGB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
2
Known Names
1
Mechanisms
Molecular Properties
317.8
MW (Da)
1.40
ALogP
5
HBA
2
HBD
79.8
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Alpha-1a adrenergic receptor partial agonist | PARTIAL AGONIST | Alpha-1A adrenergic receptor | ✓ | ✓ |
Activity Summary
EC50 1 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor CHEMBL229 | EC50 | 7.6 | 7.6 | 25.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | EC50 | = | 25.0 | nM | 7.6 | Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO c... | 18400496 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1A adrenergic receptor | 2 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1B adrenergic receptor | 1 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1D adrenergic receptor | 1 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-2A adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine