Compound Detail
CHEMBL260428
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Basic Information
| ChEMBL ID | CHEMBL260428 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DFOQUEDJAQZZIV-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
339.4
MW (Da)
4.25
ALogP
3
HBA
1
HBD
46.9
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.39
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 CHEMBL2095188 | IC50 | 6.39 | 6.39 | 410.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 | IC50 | = | 410.0 | nM | 6.39 | Inhibition of GSK3alpha/beta in pig brain | 18345612 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18345612 | 10.1021/jm701582f | Glycogen synthase kinase-3 | 1 |
| 18345612 | 10.1021/jm701582f | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 18345612 | 10.1021/jm701582f | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine