Compound Detail
CHEMBL260575
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL260575 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WOAORDZNFUQOSX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
261.3
MW (Da)
3.55
ALogP
2
HBA
1
HBD
41.6
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.94
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor CHEMBL229 | EC50 | 5.94 | 5.94 | 1150.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor | EC50 | = | 1150.0 | nM | 5.94 | Agonist activity at human cloned adrenergic alpha-1A receptor expressed in CHO c... | 18400496 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1A adrenergic receptor | 2 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1B adrenergic receptor | 1 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-1D adrenergic receptor | 1 |
| 18400496 | 10.1016/j.bmcl.2008.03.070 | Alpha-2A adrenergic receptor | 1 |
Data from ChEMBL 36 via Core Engine