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Compound Detail

CHEMBL264534

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CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)O

Basic Information

ChEMBL ID CHEMBL264534
Phase Preclinical
Structure Type BOTH
InChI Key OYCOXIWUNFSKDJ-MNBFHEIESA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

1084.3
MW (Da)

Drug Information

Molecule Type Protein
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C51H85N15O11
MW 1084.33

Activity Summary

Ki 1 meas. best 10.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neurotensin receptor type 1
CHEMBL3570
Ki 10.62 10.62 0.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Neurotensin receptor type 1 Ki = 0.024 nM 10.62 Inhibition of specific binding of [125I]-Tyr3-NT(1-13) to NT receptors in neonat... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80698-8 Neurotensin receptor type 1 1

Data from ChEMBL 36 via Core Engine