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Compound Detail

CHEMBL267941

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CN(c1ccccc1)c1cc2c(cc1N(C)c1ccccc1)C(=O)NC2=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL267941
Phase Preclinical
Structure Type MOL
InChI Key PNXRSOJTSRJLPV-UHFFFAOYSA-N
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

357.4
MW (Da)
4.11
ALogP
4
HBA
1
HBD
52.6
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H19N3O2
MW 357.41
Aromatic Rings 3
Heavy Atoms 27
NP-Likeness -0.41

Literature References

PubMed DOI Target Context # Activities
8151612 10.1021/jm00033a019 Epidermal growth factor receptor 1
8151612 10.1021/jm00033a019 Tyrosine-protein kinase ABL 1
8151612 10.1021/jm00033a019 Proto-oncogene tyrosine-protein kinase Src 1
8151612 10.1021/jm00033a019 Protein kinase C (PKC) 1
8151612 10.1021/jm00033a019 cAMP-dependent protein kinase alpha-catalytic subunit 1

Data from ChEMBL 36 via Core Engine