Compound Detail
CHEMBL270346
MERIOLIN 9 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL270346 |
| Name | MERIOLIN 9 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CPQCGVRZSBLZLT-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names
Molecular Properties
255.3
MW (Da)
1.62
ALogP
6
HBA
1
HBD
78.8
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 4.6 | 4.6 | 25000.0 | 1 |
| Cyclin-dependent kinase 5/CDK5 activator 1 CHEMBL1907600 | IC50 | 4.14 | 4.14 | 73000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 25000.0 | nM | 4.6 | Inhibition of starfish oocyte CDK1/cyclin B | 18232649 |
| Cyclin-dependent kinase 5/CDK5 activator 1 | IC50 | = | 73000.0 | nM | 4.14 | Inhibition of recombinant GST-CDK5/p25 expressed in Escherichia coli | 18232649 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18232649 | 10.1021/jm700940h | Unchecked | 3 |
| 18232649 | 10.1021/jm700940h | Cyclin-dependent kinase | 3 |
| 18232649 | 10.1021/jm700940h | Cyclin-dependent kinase 2/cyclin A | 1 |
| 18232649 | 10.1021/jm700940h | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 18232649 | 10.1021/jm700940h | CDK9/cyclin T1 | 1 |
| 18232649 | 10.1021/jm700940h | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 18232649 | 10.1021/jm700940h | SH-SY5Y | 1 |
| 18232649 | 10.1021/jm700940h | HEK293 | 1 |
| 18232649 | 10.1021/jm700940h | GBM | 1 |
| 18232649 | 10.1021/jm700940h | KMS-11 | 1 |
| 18232649 | 10.1021/jm700940h | LS174T | 1 |
| 27171036 | 10.1021/acs.jmedchem.6b00150 | CDK9/cyclin T1 | 1 |
| 27171036 | 10.1021/acs.jmedchem.6b00150 | Cyclin-dependent kinase 5/CDK5 activator 1 | 1 |
| 27171036 | 10.1021/acs.jmedchem.6b00150 | CDK2/Cyclin A2 | 1 |
| 27171036 | 10.1021/acs.jmedchem.6b00150 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine