Compound Detail
CHEMBL271276
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Basic Information
| ChEMBL ID | CHEMBL271276 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LRYUALJXKCLBKM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
246.3
MW (Da)
3.35
ALogP
2
HBA
0
HBD
17.3
PSA (Ų)
0.56
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 CHEMBL3227 | IC50 | 9.4 | 9.4 | 0.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 5 | IC50 | = | 0.3981 | nM | 9.4 | Antagonist activity at human mGluR5 expressed in CHO cells assessed as increase ... | 18304814 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18304814 | 10.1016/j.bmcl.2008.02.024 | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine