Compound Detail
CHEMBL271696
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Basic Information
| ChEMBL ID | CHEMBL271696 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PXNIHIPOYNSNAR-ONEGZZNKSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
285.3
MW (Da)
1.06
ALogP
4
HBA
2
HBD
78.5
PSA (Ų)
0.64
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Methionine aminopeptidase 1 CHEMBL2474 | Ki | 8.0 | 8.0 | 10.0 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.3 | 7.3 | 50.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Methionine aminopeptidase 1 | Ki | = | 10.0 | nM | 8.0 | Inhibition of human methionine aminopeptidase 1 | 18343108 |
| Unchecked | Ki | = | 50.0 | nM | 7.3 | Inhibition of Escherichia coli methionine aminopeptidase 1 | 18343108 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18343108 | 10.1016/j.bmcl.2008.02.066 | Unchecked | 1 |
| 18343108 | 10.1016/j.bmcl.2008.02.066 | Methionine aminopeptidase 1 | 1 |
| 38170998 | 10.1021/acs.jmedchem.3c01615 | Sortase A | 1 |
| 38170998 | 10.1021/acs.jmedchem.3c01615 | Staphylococcus aureus | 1 |
Data from ChEMBL 36 via Core Engine