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Compound Detail

CHEMBL271716

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CCC1(O)CC(=O)OCc2c1cc1n(c2=O)Cc2c-1nc1cc(Cl)c(F)cc1c2C[n+]1ccccc1.[Cl-]

Basic Information

ChEMBL ID CHEMBL271716
Phase Preclinical
Structure Type MOL
InChI Key WCHVAIAIKRHZSS-UHFFFAOYSA-M
Parent Compound CHEMBL1182899
Active Moiety CHEMBL1182899
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

506.9
MW (Da)
3.60
ALogP
6
HBA
1
HBD
85.3
PSA (Ų)
0.30
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H22Cl2FN3O4
MW 542.39
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness 0.33

Activity Summary

IC50 1 meas.

Literature References

PubMed DOI Target Context # Activities
18207748 10.1016/j.bmc.2007.10.046 A549 2
18207748 10.1016/j.bmc.2007.10.046 LoVo 1
18207748 10.1016/j.bmc.2007.10.046 MCF7 1

Data from ChEMBL 36 via Core Engine