Compound Detail
CHEMBL274016
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL274016 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWKMZCWRZDFTOY-GKFVBPDJSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
343.6
MW (Da)
6.43
ALogP
1
HBA
1
HBD
29.1
PSA (Ų)
0.25
QED
1
Ro5 Violations
16
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 CHEMBL3571 | Ki | 8.0 | 6.765 | 9.9 | 2 |
| Cannabinoid receptor 2 CHEMBL5373 | Ki | 6.65 | 6.65 | 226.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Ki | = | 9.91 | nM | 8.0 | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in ... | 9876105 |
| Cannabinoid receptor 2 | Ki | = | 226.0 | nM | 6.65 | Binding affinity towards Cannabinoid receptor 2 from mouse spleen membranes usin... | 9876105 |
| Cannabinoid receptor 1 | Ki | = | 2980.0 | nM | 5.53 | Binding affinity towards cannabinoid receptor 1 from rat forebrain membranes in ... | 9876105 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9876105 | 10.1021/jm970257g | Cannabinoid receptor 1 | 2 |
| 9876105 | 10.1021/jm970257g | Cannabinoid receptor 2 | 1 |
| 10328303 | 10.1016/s0960-894x(99)00148-1 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine