Compound Detail
CHEMBL274226
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Basic Information
| ChEMBL ID | CHEMBL274226 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YVMADKYPKNLVGU-BVUBDWEXSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
2.41
ALogP
3
HBA
3
HBD
86.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 4.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 4.99 | 4.99 | 10170.0 | 1 |
| Glutamate receptor ionotropic, kainate 1 CHEMBL1918 | Ki | 4.77 | 4.77 | 17130.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 10170.0 | nM | 4.99 | Inhibition of [3H]KA binding to human iontropic glutamate receptors 5 and 6 | 15974569 |
| Glutamate receptor ionotropic, kainate 1 | Ki | = | 17130.0 | nM | 4.77 | Inhibition of [3H]-KA binding to iontropic glutamate receptor 5 | 15974569 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15974569 | 10.1021/jm0491952 | Unchecked | 3 |
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate receptor ionotropic, AMPA | 2 |
| - | 10.1016/S0960-894X(97)00185-6 | Glutamate NMDA receptor | 2 |
| 15974569 | 10.1021/jm0491952 | Glutamate receptor 2 | 1 |
| 15974569 | 10.1021/jm0491952 | Glutamate receptor ionotropic, kainate 1 | 1 |
| 15974569 | 10.1021/jm0491952 | Glutamate receptor ionotropic, kainate 2 | 1 |
Data from ChEMBL 36 via Core Engine