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Compound Detail

CHEMBL275408

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Nc1[nH]nc2nc(-c3ccccc3)nc(O)c12
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL275408
Phase Preclinical
Structure Type MOL
InChI Key HTTMXXNJOHMNDV-UHFFFAOYSA-N
0
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

227.2
MW (Da)
1.31
ALogP
5
HBA
3
HBD
100.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H9N5O
MW 227.23
Aromatic Rings 3
Heavy Atoms 17
NP-Likeness -1.22

Activity Summary

Ki 1 meas.

Literature References

PubMed DOI Target Context # Activities
12646024 10.1021/jm0209937 Queuine tRNA-ribosyltransferase 1
- 10.6019/CHEMBL4296182 Klebsiella pneumoniae 1
- 10.6019/CHEMBL4296182 Pseudomonas aeruginosa 1
- 10.6019/CHEMBL4296182 Candida albicans 1
- 10.6019/CHEMBL4296182 Cryptococcus neoformans 1
- 10.6019/CHEMBL4296182 Staphylococcus aureus 1
- 10.6019/CHEMBL4296182 Escherichia coli 1
- 10.6019/CHEMBL4296182 Acinetobacter baumannii 1

Data from ChEMBL 36 via Core Engine