Compound Detail
CHEMBL276708
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Basic Information
| ChEMBL ID | CHEMBL276708 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOZUJQGSHJMDSB-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
256.1
MW (Da)
0.72
ALogP
5
HBA
4
HBD
123.8
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate [NMDA] receptor CHEMBL2094124 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Unchecked CHEMBL612545 | IC50 | 8.7 | 8.11 | 2.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate [NMDA] receptor | IC50 | = | 0.5 | nM | 9.3 | Compound was tested in vitro for its inhibitory activity at 1 uM concentration a... | 11909726 |
| Unchecked | IC50 | = | 2.0 | nM | 8.7 | Compound was tested in vitro for its inhibitory activity against Xenopus laevis ... | 11909726 |
| Unchecked | IC50 | = | 30.0 | nM | 7.52 | Compound was tested in vitro for its inhibitory activity against Xenopus laevis ... | 11909726 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11909726 | 10.1016/s0960-894x(02)00074-4 | Mus musculus | 3 |
| 11909726 | 10.1016/s0960-894x(02)00074-4 | Unchecked | 2 |
| 11909726 | 10.1016/s0960-894x(02)00074-4 | Glutamate [NMDA] receptor | 1 |
| 11909726 | 10.1016/s0960-894x(02)00074-4 | Glutamate receptor ionotropic, NMDA 3A | 1 |
Data from ChEMBL 36 via Core Engine