Compound Detail
CHEMBL277850
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COc1ccc(CN(CCN(C)CCCCCCCCNC(=O)c2ccc(C(=O)O)c(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c2)c2ccccn2)cc1
Basic Information
| ChEMBL ID | CHEMBL277850 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UMNFRBCAPUJRHJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
756.9
MW (Da)
8.08
ALogP
9
HBA
3
HBD
145.4
PSA (Ų)
0.05
QED
2
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H1 receptor CHEMBL3943 | Kd | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H1 receptor | Kd | = | 5.012 | nM | 8.3 | Histamine H1 receptor antagonistic activity in guinea pig ileum using fluorescen... | 12657255 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12657255 | 10.1016/s0960-894x(03)00113-6 | Histamine H1 receptor | 2 |
Data from ChEMBL 36 via Core Engine